Amino acid sequence changes in the haemagglutinin of A/Hong Kong (H3N2) influenza virus during the period 196877
Identifieur interne : 000192 ( 1968/Analysis ); précédent : 000191; suivant : 000193Amino acid sequence changes in the haemagglutinin of A/Hong Kong (H3N2) influenza virus during the period 196877
Auteurs : W. G. Laver [Australie] ; G. M. Air [Australie] ; T. A. Dopheide ; C. W. WardSource :
- Nature [ 0028-0836 ] ; 1980-01-31.
Abstract
Haemagglutinin molecules from nine strains of A/Hong Kong/68 (H3N2) influenza virus, isolated between 1968 and 1977, were examined for changes in amino acid sequences. At least 18 changes, 9 of which were located precisely, occurred in the soluble tryptic peptides of the large haemagglutinin polypeptide (HA1) during this period. These peptides contained 262 residues (82% of HA1). In HA2, only two changes in 129 residues (58% of HA2) were detected. Sequential changes at a particular locus were not found; and as far as we can tell, once an amino acid changed, it did not change again in any subsequent variant examined.
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DOI: 10.1038/283454a0
Affiliations:
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G." last="Laver">W. G. Laver</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra City, ACT, 2601, AustraliaCSIRO, Division of Protein Chemistry, 343 Royal Parade, Parkville, Victoria 3052</wicri:regionArea><wicri:noRegion>Victoria 3052</wicri:noRegion></affiliation></author><author><name sortKey="Air, G M" sort="Air, G M" uniqKey="Air G" first="G. M." last="Air">G. M. Air</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra City, ACT, 2601, AustraliaCSIRO, Division of Protein Chemistry, 343 Royal Parade, Parkville, Victoria 3052</wicri:regionArea><wicri:noRegion>Victoria 3052</wicri:noRegion></affiliation></author><author><name sortKey="Dopheide, T A" sort="Dopheide, T A" uniqKey="Dopheide T" first="T. A." last="Dopheide">T. A. Dopheide</name></author><author><name sortKey="Ward, C W" sort="Ward, C W" uniqKey="Ward C" first="C. W." last="Ward">C. W. Ward</name></author></analytic><monogr></monogr><series><title level="j" type="main">Nature</title><imprint><publisher>Nature Publishing Group</publisher><date when="1980-01-31">1980-01-31</date><biblScope unit="vol">283</biblScope><biblScope unit="issue">5746</biblScope><biblScope unit="page" from="454">454</biblScope><biblScope unit="page" to="457">457</biblScope><date type="Copyright" when="1980">1980</date></imprint><idno type="ISSN">0028-0836</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0028-0836</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Haemagglutinin molecules from nine strains of A/Hong Kong/68 (H3N2) influenza virus, isolated between 1968 and 1977, were examined for changes in amino acid sequences. At least 18 changes, 9 of which were located precisely, occurred in the soluble tryptic peptides of the large haemagglutinin polypeptide (HA1) during this period. These peptides contained 262 residues (82% of HA1). In HA2, only two changes in 129 residues (58% of HA2) were detected. Sequential changes at a particular locus were not found; and as far as we can tell, once an amino acid changed, it did not change again in any subsequent variant examined.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Dopheide, T A" sort="Dopheide, T A" uniqKey="Dopheide T" first="T. A." last="Dopheide">T. A. Dopheide</name><name sortKey="Ward, C W" sort="Ward, C W" uniqKey="Ward C" first="C. W." last="Ward">C. W. Ward</name></noCountry><country name="Australie"><noRegion><name sortKey="Laver, W G" sort="Laver, W G" uniqKey="Laver W" first="W. G." last="Laver">W. G. Laver</name></noRegion><name sortKey="Air, G M" sort="Air, G M" uniqKey="Air G" first="G. M." last="Air">G. M. Air</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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